Steven talks to Alzforum about our recent work on nucleocytoplasmic transport defects in C9orf72 ALS/FTLD.
Our collaborative paper with the Bullock and Van den Bosch labs is online at BioRxiv! Was great to work together with Laura Fumagalli and Florence Young on this. We discovered that C9orf72 arginine-rich DPRs perturb axonal transport by directly engaging the microtubules and associated motor complexes.
Collaborative paper with the Van den Bosch lab is accepted at Scientific Reports! Congrats Joni Vanneste for all the hard work! We show that C9orf72 arginine-rich DPRs do not directly cause nucleocytoplasmic transport defects, but rather act indirectly via triggering the cellular stress response.
New website goes live!