Steven gave a talk on the role of phase separation in ALS and SCA at the Center for Brain & Disease Research at VIB-KU Leuven. Great to see some familiar faces and sit together with students and postdocs to hear all about the exciting research going on.
Our collaborative paper with the Isaacs lab is online at Acta Neuropathologica! Lauren Gittings found that symmetric dimethylation of GR is correlated with increased survival in C9orf72 patients. Such a protective role was further supported by our analyses indicating that dimethylation affects the phase separation capacity of GR and reduces its neuronal toxicity. We reported years ago that arginine methyltransferases are genetic modifiers of DPR toxicity in Drosophila. Good to see we now finally have convincing data from patients supporting this!
Steven talks to Alzforum about our recent work on nucleocytoplasmic transport defects in C9orf72 ALS/FTLD.
Our collaborative paper with the Bullock and Van den Bosch labs is online at BioRxiv! Was great to work together with Laura Fumagalli and Florence Young on this. We discovered that C9orf72 arginine-rich DPRs perturb axonal transport by directly engaging the microtubules and associated motor complexes.
Collaborative paper with the Van den Bosch lab is accepted at Scientific Reports! Congrats Joni Vanneste for all the hard work! We show that C9orf72 arginine-rich DPRs do not directly cause nucleocytoplasmic transport defects, but rather act indirectly via triggering the cellular stress response.
New website goes live!