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Publication list

[PubMed] [Google Scholar]

Preprints

Fumagalli F*, Young FL*, Boeynaems S*, De Decker M, Mehta A, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Bhuvaneish TS, Vandoorne T, Madan V, van Blitterswijk M, Raitcheva D, McCampbell A, Poesen K, Gitler AD, Koch P, Vanden Berghe P, Thal DR, Verfaillie C, Chandran S, Van Den Bosch L, Bullock S, Van Damme P. C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility. BioRxiv 2019. co-first

2019

Gittings L, Boeynaems S, Lightwood D, Clargo A, Topia S, Nakayama L, Troakes C, Mann D, Gitler AD, Lashley T, Isaacs A. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity. Acta Neuropathologica (accepted).

Vanneste J, Vercruysse T, Boeynaems S, Sicart A, Van Damme P, Daelemans D, Van Den Bosch L. C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport. Scientific Reports, vol. 9, article number: 15728.

Boeynaems S and Gitler AD. Axons Gonna Ride 'til They Can't No More. Neuron, vol. 104(2), p. 179-181.

Boeynaems S, Holehouse AS, Weinhardt V, Kovacs D, Van Lindt J, Larabell C, Van Den Bosch L, Das R, Tompa P, Pappu RV, Gitler AD. Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties. PNAS, vol. 116(16), p. 7889-7898. co-corresponding

2018

Boeynaems S and Gitler AD. Pour Some Sugar on TDP (-43). Molecular Cell, vol. 71(5), p. 649-651.

Bogaert E*, Boeynaems S*, Kato M, Guo L, Caulfield TR, Steyaert S, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz S, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L. Molecular dissection of FUS points at synergistic effect of low-complexity domains in toxicity. Cell Reports, vol. 24(3), p. 529-537. co-first, co-corresponding
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Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa T, Fuxreiter M. Protein phase separation: a new phase in cell biology. Trends in Cell Biology, vol. 28(6), p. 420–435. co-corresponding
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Boeynaems S and Gitler AD. Phosphorylation Leads the Way for Protein Aggregate Disassembly. Developmental Cell , vol. 45(3), p. 279-281.

Swinnen B, Boeynaems S, Schrooten M, Saegeman V, Claeys KG, Van Damme P. Anterior interosseous mononeuropathy associated with HEV infection. Neurology - Neuroimmunology Neuroinflammation, vol. 5(2), e429.

Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs A, Petrucelli L, Van Damme P, Van Den Bosch L, Robberecht W. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Acta Neuropathologica, vol. 135(3), p. 427–443.

Boeynaems S, Tompa P, Van Den Bosch L. Phasing in on the cell cycle. Cell Division, vol. 13(1). corresponding

2017

Boeynaems S, De Decker M, Tompa P, Van Den Bosch L. Arginine-rich Peptides Can Actively Mediate Liquid-liquid Phase Separation. Bio-protocol, vol. 7(17).

Boeynaems S
, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L. Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics. Molecular Cell, vol. 65(6), p. 1044-1055.
featured on the cover

2016

Boeynaems S, Bogaert E, Van Damme P, Van Den Bosch L. Inside out: the role of nucleocytoplasmic transport in ALS and FTLD. Acta Neuropathologica, vol. 132(2), p. 159-173. co-corresponding

Boeynaems S*, Bogaert E*, Michiels E, Gijselinck I, Sieben A, Jovicic A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L. Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD. Scientific Reports, vol. 6, article number: 20877. co-first

2015

Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW 3rd, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nature Neuroscience, vol. 18(9), p. 1226-1229.

Gemayel R, Chavali S, Pougach K, Legendre M, Zhu B, Boeynaems S, van der Zande E, Gevaert K, Rousseau F, Schymkowitz J, Babu MM, Verstrepen KJ. Variable glutamine-rich repeats modulate transcription factor activity. Molecular Cell, vol. 59(4), p. 615-627. 

2012

Gemayel R, Cho J, Boeynaems S, Verstrepen KJ. Beyond junk - variable tandem repeats as facilitators of rapid evolution of regulatory and coding sequences. Genes, vol. 3(3), p. 461-480.